Driving Biomedical Projects (DBPs)

Institution Project title Investigator Grant number
USC Structure and function of opioid and cannabinoid receptors Vadim Cherezov R35GM127086, P01DA035764
UW Design and structure of self assembling crystals David Baker R01AG063845
Caltech Innovation by evolution: bringing new chemistry to life Frances Arnold R01GM138740
U Wisconsin Design and structure of polymers Samuel Gellman R01GM061238
U Illinois A scalable platform to discover antimicrobials of ribosomal origin Wilfred van der Donk R01AI144967
U Notre Dame Chemical approaches to selectively target β-rich amyloids Juan Del Valle R01AG074570
UNL Structural bases of tight junction form, function, and disruption Alex J. Veccio R35GM138368
Yale University Structural investigation of rapafucins Jun Liu R01GM137319
Stanford Structural investigation of GPCRs Georgios Skiniotis R01NS122394, R01GM083118
UCLA Novel membrane permeable macrocycles Patrick Harran R21AI168952
UC Berkeley, Yale Structural analysis of macrocycles containing embedded, atropisomeric pharmacophores Alanna Schepartz (UC Berkeley), Scott Miller (Yale) NSF CHE-2002182

Completed projects

Institution Investigator Project title
Duke Robert Lefkowitz Molecular regulation of cardiovascular 7-TM receptors
UVa/Miami Mark Yeager Structure analysis of viral assembly mechanisms
Notre Dame Anthony Serianni Identification of glucosidases
UCLA Jeff Abramson Functional and structural studies of unique pathogenic transporters in glycobiology
UC Berkeley James Hurley Structure of human ESCRT-I complex
Caltech Pamela Bjorkman Targeting the HIV reservoir using optimized anti-HIV antibodies
UCLA Juli Feigon Structure and function of human telomerase
CU Denver Hongjin Zheng Mechanistic studies of prokaryotic and eukaryotic nitrate/nitrite transport