One of expected areas where MicroED may have an outstanding role is for proteins and complexes where crystal growth tend to yield smaller crystals only. Membrane proteins puts many challenges to the crystallographer and often a two phase systems as Lipid Cubic Phase (LCP) is needed. The authors shows the feasibility of using LCP in the cryoEM setting required by MicroED

Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED.Zhu L, Bu G, Jing L, Shi D, Lee MY, Gonen T, Liu W, Nannenga BL.